Genetic Testing for Coeliac Disease

Will determine if you carry the HLA DQ2 and DQ8 genes associated with an increased risk of coeliac disease. Only £115

Only £115 with results in 2-3 weeks

Over 80% of people suffering from coeliac disease are unaware that they have the condition. Are you? To be sure, why not consider Genetic Testing for Coeliac Disease to find out if you have the genes associated with an increased risk of developing the condition?

Our coeliac disease test uses Human Leukocyte Antigen (HLA)-typing to confirm or exclude the possibility of coeliac disease by testing 6 DNA markers for the HLA DQ2 and DQ8 genes.

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What is Coeliac Disease?

Coeliac disease is what’s known as a genetic autoimmune disorder caused by an intolerance to gluten. Left untreated, it can lead to serious complications, which could negatively impact on your quality of life. Symptoms include: stomach pain, bloating and flatulence (passing wind), diarrhoea, indigestion and constipation. Coeliac disease can also cause more general symptoms such as fatigue, weight loss, an itchy rash and difficulties with getting pregnant.

Click here to read more about coeliac disease symptoms.

If you think that you may have the condition, it could be well worth your while doing Genetic Testing for Coeliac Disease to see whether or not you carry the genes related to the disease. By doing so, you will essentially be able to rule out having coeliac disease with more than 99% accuracy.

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Advantages of Genetic Testing for Coeliac Disease

If you suspect that the symptoms you are experiencing may be caused by coeliac disease, you have probably given some thought to your next move, in terms of diagnosis and screening. Genetic Testing for Coeliac Disease is a screening option that carries a number of advantages.

  • Many people who are concerned that they may be coeliac opt to follow a gluten-free diet in an effort to manage their symptoms. However, if the DNA test rules out coeliac disease, you can reintroduce gluten into your diet.
  • It is important to know that having a close relative who is coeliac means that you face an increased risk of also developing the disease, as it is known that it can be inherited.
  • Only by undergoing Genetic Testing for Coeliac Disease will you be able to establish if you carry the genes associated with coeliac disease.
  • One commonly used test for coeliac disease is to test the antibodies in the blood. However, even if you do suffer from the condition, this type of test can only be successfully carried out if you are currently eating foods containing gluten. A genetic test can be run irrespective of what diet you are currently following and at any age.
  • Negative results for both HLA-DQ types make a coeliac disease diagnosis highly unlikely. The negative predictive value is greater than 99%.

Click here to view a Sample Coeliac Disease Report:

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Genetic Testing for Coeliac Disease is a Simple Process

Genetic Testing for Coeliac Disease does not require you to give a blood sample. Our test is carried out using the mouth swabs provided for you in our home sample collection kit. The test is quick and simple to administer, providing that you carefully adhere to the instructions and precautions provided.

You can view sample collection instructions on our How to Collect DNA Samples page.

It is important to note that this test is not diagnostic. It will though, tell you whether or not you carry the genes that can trigger coeliac disease. If your results show that you do carry these genes, this does not mean you currently have the disease, nor that you will necessarily develop it. However, if the test results show that you don’t carry the relevant genes, you can rest assured that you will never suffer from it.

The clinical diagnosis of coeliac disease generally requires you to undergo a biopsy, which will help to reveal how damaged the intestinal walls have become, and whether the particular presentation of damage has been caused by coeliac disease.

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Genes Associated with Coeliac Disease

The two genes most often observed in people with this particular disease are HLA DQ2 and DQ8. While these are the two most commonly occurring genes associated with the condition, they are not the only ones implicated. HLA (Human Leukocyte Antigen) produces a certain protein which is designed to hold any bacteria, viruses or other foreign particles on the cell’s surface. In the case of those people who carry HLA genes that are defective, the human body cannot accurately distinguish HLA from gluten, which triggers an auto-immune reaction.

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Living with Coeliac Disease

The seriousness of coeliac disease depends on a number of factors. These include how long you have been suffering from it, how old you are and for how many years you have been eating gluten.

There is currently no cure and no drug therapy available to those suffering from coeliac disease. Instead, you will need to follow a strict gluten-free diet, as this is the only certain way to avoid damaging the small intestine mucosa. If you are diagnosed with coeliac disease, you will need to ensure your progress is carefully monitored by your GP or another healthcare provider.

Please read our Health and Clinical Testing Terms and Conditions carefully and make sure you understand them before placing an order.

Please Contact Us with any questions you might have or to place an order.

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Other Genetic Tests: Lactose Intolerance DNA Test

Read more about the Lactose Intolerance DNA Test which will determine if your genotype is related to a high or low risk of developing lactose intolerance.

Disclaimer: Your test results are solely for informational and/or educational purposes only and should NOT be used for making medical, health or any other decisions without consulting a medical professional. Always speak to your doctor and seek professional help before taking action. The test does not replace a visit to a doctor, nor the advice or services of a doctor or other qualified specialist.

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