Genetic Testing for Coeliac Disease

Will determine if you carry the genes associated with an increased risk of coeliac disease. From only £69

From only £69 with results in 5-7 working days

Over 80% of people suffering from coeliac disease are unaware that they have the condition. Are you? To be sure, why not consider Genetic Testing for Coeliac Disease to find out if you have the genes associated with an increased risk of developing the condition?

Our coeliac disease test uses Human Leukocyte Antigen (HLA)-typing to confirm or exclude the possibility of coeliac disease by examining the main 2 or 16 DNA markers.

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What is Coeliac Disease?

Coeliac disease is what’s known as a genetic autoimmune disorder caused by an intolerance to gluten. Left untreated, it can lead to serious complications, which could negatively impact on your quality of life. Symptoms include: stomach pain, bloating and flatulence (passing wind), diarrhoea, indigestion and constipation. Coeliac disease can also cause more general symptoms such as fatigue, weight loss, an itchy rash and difficulties with getting pregnant.

Click here to read more about coeliac disease symptoms.

If you think that you may have the condition, it could be well worth your while doing Genetic Testing for Coeliac Disease to see whether or not you carry the genes related to the disease.

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Advantages of Genetic Testing for Coeliac Disease

If you suspect that the symptoms you are experiencing may be caused by coeliac disease, you have probably given some thought to your next move, in terms of diagnosis and screening. Genetic Testing for Coeliac Disease is a screening option that carries a number of advantages.

  • Many people who are concerned that they may be coeliac opt to follow a gluten-free diet in an effort to manage their symptoms. However, if the DNA test rules out coeliac disease, you can reintroduce gluten into your diet.
  • It is important to know that having a close relative who is coeliac means that you face an increased risk of also developing the disease, as it is known that it can be inherited.
  • Only by undergoing Genetic Testing for Coeliac Disease will you be able to establish if you carry the genes associated with coeliac disease.
  • One commonly used test for coeliac disease is to test the antibodies in the blood. However, even if you do suffer from the condition, this type of test can only be successfully carried out if you are currently eating foods containing gluten. A genetic test can be run irrespective of what diet you are currently following and at any age.

We offer 2 types of tests:

  • Standard Test (for £69)

Our Standard test determines the main two alleles belonging to the HLA family related to celiac disease. The DQ2.5*02 genetic variant, present in 90-95% of celiac subjects, and the DQ8, *0302 genetic variant, present in the remaining 10-5% of celiac subjects are evaluated.

The test on 2 genetic markers can be used for the following purposes in the diagnosis of Celiac Disease:

  • To derive complex diagnoses in case there are interpretative difficulties between serology and biopsy.
  • To confirm a diagnostic test.
  • For an adequate preventive strategy.

 

  • Extended Test (for £99)

The test on 16 genetic markers in addition to the points above has also the following purposes:

  • To exclude the disease in case of a negative result.
  • To determine your “risk class” of developing celiac disease.
  • To determine the HLA structure of the relatives of the celiac.

In short, in case of positivity (where at least one of the markers is not showing low susceptibility), the standard test (with 2 markers) requires confirmation with a serological test or an intestinal biopsy or the extended test (with 16 markers) which on the other hand, gives the attribution to a risk class ranging from high to very low.

In case of negativity, with the standard test (where both markers are showing low susceptibility) the coeliac disease diagnosis is highly unlikely and the negative predictive value is greater than 99%, whilst with the extended test, this can even be considered as a diagnostic test and you can rest assured that you will never suffer from coeliac disease.

Click here to view the two  Sample Coeliac Disease Reports:

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Genetic Testing for Coeliac Disease is a Simple Process

Genetic Testing for Coeliac Disease does not require you to give a blood sample. Our test is carried out using the mouth swabs provided for you in our home sample collection kit. The test is quick and simple to administer, providing that you carefully adhere to the instructions and precautions provided.

You can view sample collection instructions on our How to Collect DNA Samples page.

It is important to note that the standard test is not diagnostic whilst the extended test can be considered diagnostic when  the result is negative. Both tests tell you whether or not you carry the genes that can trigger coeliac disease. If your results (from the standard or from the extended test) show that you do carry these genes, this does not mean you currently have the disease, nor that you will necessarily develop it.

The clinical diagnosis of coeliac disease generally requires you to undergo a biopsy, which will help to reveal how damaged the intestinal walls have become, and whether the particular presentation of damage has been caused by coeliac disease.

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Living with Coeliac Disease

The seriousness of coeliac disease depends on a number of factors. These include how long you have been suffering from it, how old you are and for how many years you have been eating gluten.

There is currently no cure and no drug therapy available to those suffering from coeliac disease. Instead, you will need to follow a strict gluten-free diet, as this is the only certain way to avoid damaging the small intestine mucosa. If you are diagnosed with coeliac disease, you will need to ensure your progress is carefully monitored by your GP or another healthcare provider.

Please read our Health and Clinical Testing Terms and Conditions carefully and make sure you understand them before placing an order.

Please Contact Us with any questions you might have or to place an order.

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Other Genetic Tests: Lactose Intolerance DNA Test

Read more about the Lactose Intolerance DNA Test which will determine if your genotype is related to a high or low risk of developing lactose intolerance.

Disclaimer: Your test results are solely for informational and/or educational purposes only and should NOT be used for making medical, health or any other decisions without consulting a medical professional. Always speak to your doctor and seek professional help before taking action. The test does not replace a visit to a doctor, nor the advice or services of a doctor or other qualified specialist.

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