Multidrug Resistance 1 MDR1 Test

A health screening test for your dog to determine if it carries the mutated MDR1 gene.

Only £55 with results in 7 working days

The Multidrug Resistance 1 MDR1 Test is a fast and effective way of determining whether or not your dog has the mutated Multidrug Resistance MDR1 gene, also known as the ABCB1 gene, or is likely to pass it on to any offspring.

IMPORTANT: Please check the list below of breeds that can be tested for MDR1 before ordering. We can only test the breeds listed below and cancellation charges will apply for orders placed for breeds that we do not test.

AffinityDNA DNA Helix Icon Multidrug Resistance 1 MDR1 Test

What is Multidrug Resistance 1?

Multidrug Resistance 1 is inherited as an autosomal incomplete dominant disease. The MDR1 gene codes for the production of a protein known as p-glycoprotein. P-glycoprotein acts as a pump that removes certain drugs and toxins from the body. A mutation in the ABCB1 gene associated with MDR1 prohibits P-glycoprotein’s ability to limit absorption, distribution, and excretion of drugs and allows higher levels of drugs to enter the brain.

Dogs only need to inherit one copy of the MDR1 mutation to be at risk for sensitivity to certain drugs. Dogs with two copies of the MDR1 mutation can have more severe reactions such as excess salivation, tremors, anorexia, blindness and possibly death.

MDR1 affected dogs are at risk of developing neurologic symptoms from several common drugs including Acepromazine (tranquiliser), Butorphanol (pain control), Doramectin, Doxorubicin, Emodepside, Erythromycin, Ivermectin (found in heartworm medications), Loperamide (anti-diarrheal agent), Milbemycin, Moxidectin, Paclitaxel, Rifampicin, Selamectin, Vinblastine (anti-cancer agent), Vincristine and Vinorelbine.

Other medications may also cause a reaction and you should inform your veterinarian if your dog is a MDR1-carrier or MDR1-affected so they can adjust dosage or provide an alternative medication.

AffinityDNA DNA Helix Icon Multidrug Resistance 1 MDR1 Test

Which Breeds Can Be Tested for Multidrug Resistance 1 MDR1?

The Multidrug Resistance 1 MDR1 Test can be carried out on the following breeds:

  • Aussiedoodle
  • Australian Cobber Dog
  • Australian Shepherd
  • Border Collie
  • Collie
  • Czech Wolfdog
  • Czech Vlcak
  • English Shepherd
  • German Shepherd Dog
  • Longhaired Whippet
  • McNab Shepherd
  • Miniature Australian Shepherd
  • Old English Sheepdog
  • Shetland Sheepdog
  • Shiloh Shepherd
  • Smooth Collie
  • Waller
  • White Shepherd
  • White Swiss Shepherd

We can test mixed breed dogs as long as one or more of the breeds is listed above. However, it should be noted that the test results will only be relevant to the breed(s) on the list. We cannot test for breeds that are not included in the list above.

AffinityDNA DNA Helix Icon

What will Multidrug Resistance 1 MDR1 Test Results Tell You?

Using a simple swab from the inner cheek of your dog, we will ascertain whether your dog carries the mutated MDR1 gene, which allows you to make an informed choice as to whether or not to breed from the dog.

Once we receive the dog’s buccal swabs, we undertake tests that will give one of three possible outcomes:

  1. A CLEAR result shows that the dog has inherited two genes from its parents that are mutation free and will not be affected by MDR1.
  2. A CARRIER result indicates that the dog has inherited one normal copy of the MDR1 gene, and one mutation. This means that the dog has an increased risk of drug sensitivity.
  3. An AFFECTED result indicates that the dog has inherited two copies of the mutated MDR1 gene from its parents and is at risk of adverse drug reactions.

Please click on the image below to view our Multidrug Resistance 1 MDR1 Test Result Chart:

Multidrug Resistance 1 MDR1 Test Result Chart

AffinityDNA DNA Helix Icon

Other Dog DNA Tests from AffinityDNA

As well as the Multidrug Resistance 1 MDR1 Test we also offer a range of inherited disease screening tests including:

Dog Allergy Testing, Dog Parentage Testing and a choice of dog DNA breed tests which include information about the personality traits and predisposition to diseases for each breed found in your dog’s DNA. Please click on each of the links below for more information:

If you have any questions about the Multidrug Resistance 1 MDR1 Test for your dog, please do not hesitate to Contact our Customer Service Team who will be happy to help you.

ORDER NOW

Paternity Test Kits Review
Thank you so much for your help with this. A very professional and caring service. Reminds me how very different customer services are in UK compared to the service accepted by most people here in Spain. Thanks again.
D.H.
June 2021
Dog Allergy Testing Review
Please forward my praise to your superiors with regards to your customer attention - thank you for all the communication at all times, and making sure all OK. Much appreciated. 1 day into eliminating salmon oil from her diet (daily supplement I was giving her for for her arthritis) and the turkey menus she is considerably better, all in 24 hrs. Can’t wait to see how she improves within a few weeks of elimination.
L.S.
April 2021
Paternity DNA Test Kit Review
You guys have honestly just kick started my life!! I’m buzzing
S.B.
March 2021
Prenatal Paternity Test Review
Thank you so much for the great service and fast results
J.T.
March 2021
Sibling DNA Test Kit Review
Again, thank you so much, the journey with Affinity DNA has been fast, efficient and the technical help amazing from beginning to the end.
J.F.
March 2021
Degenerative Myelopathy Test Review
Amazing very fast delivery and so much detailed information!
L.W.
January 2021
Father and Daughter Paternity Test Kit
I am over the moon with the service, thank you very very much.
A.P.
November 2020
Health and Fitness DNA Test Review
Many thanks for your support and the excellent service provided by your company.
A.B.
September 2020
DM Test for Dogs Review
Just a note to say thank you again for sending results in the post, which I received today. Your service & kindness is exemplary.
K.F.
August 2020
Father and Son Paternity Test Kit
Thank you so so much mark for your fast response with the results. You have absolutely made my families life with this.
J.C.
July 2020
Father Son Paternity Test Review
Thank you for our results I must say the communication and service were outstanding.
N.W.
July 2020
Paternity Test for Father and Child Review
Thank you a great result I was hoping to be the father great service at a great price.
W.B.
June 2020
Paternity Test Kit Feedback
Thank you so much for a speedy and comprehensive service. I am very pleased and impressed
A.K.
June 2020
2 Children Paternity Test Kit Review
Thank you for the test results and a quick professional service.
F.K.
May 2020
Affinity Paternity Test Review
I wish to say "big thanks" to you (and all who work with you) for your really exemplary communication and professional relationship with me.
B.B.
April 2020
Parentage DNA Test Review
Thankyou so much for this service. It is a massive relief for me to have the doubt of parentage removed. It has changed my world Thankyou.
N.S.
February 2020
DNA Paternity Tests Review
Thank you so much Mark, roller coaster of emotions but absolutely buzzing I’ve finally got what I wanted after 3 year of knowing. Really appreciate your work and will definitely recommend your services to other people who need ur service. Regards One happy dad
D.H.
January 2020
Home Paternity DNA Test Review
Thankyou so much!! The resulting wanted, you have been brilliant throughout, will always recommend you.
L.F.
January 2020
Home Paternity Test Kit Review
Thank you so much, honestly changed mine and my families life. Happy Christmas you just made mine 🙂
P.I.
December 2019
At Home Paternity Test Review
Thank you to all that work at Affinity, you have helped me to ease a lot of stress off my heart & mind & I am forever greatfull. Thank you again
J.K.
November 2019